منابع مشابه
Autophagy and ageing: implications for age-related neurodegenerative diseases.
Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An ar...
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Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modu...
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The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insuli...
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The mitochondrial genome resides within mitochondria, the principal source of intracellular reactive oxygen species, and is thus exposed to far greater oxidative stress than nuclear DNA. The mitochondrial genome also demonstrates more intensive oxidative damage and a higher mutation rate than nuclear DNA. These facts are one reason for the age-related decline in the function of various tissues ...
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ژورنال
عنوان ژورنال: Hans Journal of Biomedicine
سال: 2017
ISSN: 2161-8976,2161-8984
DOI: 10.12677/hjbm.2017.73006